PMID 15967595
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- Title
Deficits in response inhibition associated with chronic methamphetamine abuse.
- Authors
Monterosso JR, Aron AR, Cordova X, Xu J, London ED
- Year
2005
- Abstract
Chronic methamphetamine (MA) abuse is associated with cerebral deficits, involving frontal/basal-ganglia regions that are important for inhibitory control. We used the Stop-Signal Task to measure response inhibition in 11 MA abusers (5-7 days abstinent) and two groups of control subjects who did not use MA (14 tobacco smokers and 29 non-smokers). Stop-signal reaction time (SSRT), which indicates the latency to inhibit an initiated motor response, was significantly longer for MA abusers than for either control group (p's<.01). In contrast, the MA abusers did not differ from either group on Go trial reaction time (RT) or number of discrimination errors, which reflect motor speed and decision-processes, respectively. MA abuse in this study was therefore associated with a specific deficit in inhibiting a pre-potent response. Future research could examine whether SSRT is different for MA abusers who respond to treatment compared to those who do not. If such differences are established then response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials.
- Keywords
Adult, Central Nervous System Stimulants, Cluster Analysis, Female, Humans, Inhibition (Psychology), Male, Methamphetamine, Motor Activity, Prefrontal Cortex, Psychomotor Performance, Reaction Time, Substance-Related Disorders
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