Allostatic overload model
Contents
Allostatic Overload Model
Basic Characteristics
- Description
The allostatic overload model has been proposed to explain the significant enlargement of the amygdala in children with autism followed by the subsequent decrease in amygdala volume as compared to typically developing children. In this model, repeated exposure to some highly stimulating event causes a response in the amygdala to deal with the repeated stimulation. This response includes increased branching of synapses and dendritic overgrowth. The overgrowth leads to overproduction of corticotropins and glucocorticoids. After a certain threshold concentration of corticotropins and glucocorticoids is reached, these neuropeptides cause cell death in the amygdala.
References
1. Mosconi MW et. al. Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism. Arch Gen Psychiatry. 2009 May;66(5):509-16. PMID 19414710
Related Information
- Tasks or Tests to Measure Joint Attention
- Indicators (dependent variables, conditions, or contrasts; measurement variables used for analysis) associated with this construct (vote or nominate by editing this page):
- Closely related pages (vote or nominate related pages by editing this page):
- CNP Level (What's this?)
- Cognitive Concept
External Resources
- Links out:
- Wikipedia: Joint Attention
- Google: Joint Attention
- PubMed: Joint Attention
- -ucla cognitive atlas- (coming soon!)
- Database links
