RELN
From Pheno Wiki
Revision as of 14:33, 17 November 2009 by 128.97.66.134 (Talk) (Created page with '==RELN== Reelin pathway PMID RELN encodes the protein Reelin and is located on the distal long arm of chromosome 7 at 7q22. This locus has bee…')
RELN
Reelin pathway PMID
RELN encodes the protein Reelin and is located on the distal long arm of chromosome 7 at 7q22. This locus has been associated with autism susceptibility. Reelin has a critical role in cortical patterning. It is a secreted extracellular matrix protein that controls neuronal migration, cortical layering, and other things through interactions with lipoprotein receptors. Reelin levels are reduced in post-mortem studies of the brains of patients with autism. Association studies between genetic changes in RELN locus and autism have been conflicting.1
Neurobiology
References
1. Pardo, CA et. al. The Neurobiology of Autism.Brain Pathol. 2007 Oct;17(4):434-47. PMID 17919129
