Ubiquitin
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Revision as of 20:21, 13 November 2009 by 76.94.162.242 (Talk) (Created page with '==Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)== The genes UBE3A, PARK2, RFWD2 and FBXO40 are a part of the Ubiquitin pathway and have been implicated as genes that may po…')
Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)
The genes UBE3A, PARK2, RFWD2 and FBXO40 are a part of the Ubiquitin pathway and have been implicated as genes that may possibly confer susceptibility to ASD through genome wide CNV association studies. Ubiquitination is a post-translational modification that can alter protein function and target proteins for proteosome degradation. This system can regulate synaptic attributes, including neurotransmitter release, synaptic vesicle recycling in pre-synaptic terminals, dynamic changes in dendritic spines, and post-synaptic density.
UBE3A | a ubiquitin protein ligase |
PARK2 | ubiquitin-protein ligase |
RFWD2 | ubiquitin-protein ligase |
FBXO40 | ubiquitin-protein ligase |