http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&feed=atom&action=history
Ubiquitin - Revision history
2024-03-28T09:05:22Z
Revision history for this page on the wiki
MediaWiki 1.26.2
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=3715&oldid=prev
128.97.66.134 at 22:41, 14 July 2010
2010-07-14T22:41:52Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 22:41, 14 July 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Genes]]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Ubiquitin pathway.gif|frame|Ubiquitin Proteasome System PMID 19597829]]</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Ubiquitin pathway.gif|frame|Ubiquitin Proteasome System PMID 19597829]]</div></td></tr>
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128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=3062&oldid=prev
Deanna at 19:06, 2 February 2010
2010-02-02T19:06:27Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:06, 2 February 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11" >Line 11:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><br><br><br><br></del></div></td><td colspan="2"> </td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>-<del class="diffchange diffchange-inline">---</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><div style="float:right; padding:10px; background:yellow; border:2px solid black;font</ins>-<ins class="diffchange diffchange-inline">size:large;"><b>[[Autism Spectrum Disorders| Main Page]]</b></div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><br><br><br><br></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>1. Glessner JT, et. al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.Nature. 2009 May 28;459(7246):569-73 PMID 19404257</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>1. Glessner JT, et. al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.Nature. 2009 May 28;459(7246):569-73 PMID 19404257</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>2. Lehman, NL. The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 118:329–347 PMID 19597829</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>2. Lehman, NL. The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 118:329–347 PMID 19597829</div></td></tr>
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Deanna
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2866&oldid=prev
128.97.66.134 at 22:25, 14 January 2010
2010-01-14T22:25:11Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 22:25, 14 January 2010</td>
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128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2865&oldid=prev
128.97.66.134 at 22:25, 14 January 2010
2010-01-14T22:25:01Z
<p></p>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 22:25, 14 January 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l12" >Line 12:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td></tr>
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128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2864&oldid=prev
128.97.66.134 at 22:24, 14 January 2010
2010-01-14T22:24:45Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 22:24, 14 January 2010</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[<del class="diffchange diffchange-inline">Links</del>| Back to <del class="diffchange diffchange-inline">Links</del>]]<del class="diffchange diffchange-inline"></div></del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[<ins class="diffchange diffchange-inline">AIRB</ins>| Back to <ins class="diffchange diffchange-inline">Main Page</ins>]]</div></td></tr>
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</table>
128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2370&oldid=prev
Deanna at 19:28, 16 November 2009
2009-11-16T19:28:46Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:28, 16 November 2009</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[Links| Back to Links]]</div></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[Links| Back to Links]]</div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">----</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">====Criticisms===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">----</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>1. Glessner JT, et. al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.Nature. 2009 May 28;459(7246):569-73 PMID 19404257</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>1. Glessner JT, et. al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.Nature. 2009 May 28;459(7246):569-73 PMID 19404257</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>2. Lehman, NL. The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 118:329–347 PMID 19597829</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>2. Lehman, NL. The ubiquitin proteasome system in neuropathology. Acta Neuropathol (2009) 118:329–347 PMID 19597829</div></td></tr>
</table>
Deanna
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2368&oldid=prev
Deanna at 19:23, 16 November 2009
2009-11-16T19:23:44Z
<p></p>
<table class='diff diff-contentalign-left'>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:23, 16 November 2009</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Ubiquitin pathway (UBE3A, PARK2, RFWD2 and FBXO40)==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Image:Ubiquitin pathway.gif|frame|Ubiquitin Proteasome System PMID 19597829]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The genes UBE3A, PARK2, RFWD2 and FBXO40 are a part of the Ubiquitin pathway and have been implicated as genes that may possibly confer susceptibility to ASD through genome wide CNV association studies. Ubiquitination is a post-translational modification that can alter protein function and target proteins for proteosome degradation. This system can regulate synaptic attributes, including neurotransmitter release, synaptic vesicle recycling in pre-synaptic terminals, dynamic changes in dendritic spines, and post-synaptic density. All four of the genes are ubiquitin-protein ligases.  UBE3A is the most studied of the four in relation to autism and PARK2 mutations have been linked to autosomal reccessive juvenile Parkinson's disease. <sup>1</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The genes UBE3A, PARK2, RFWD2 and FBXO40 are a part of the Ubiquitin pathway and have been implicated as genes that may possibly confer susceptibility to ASD through genome wide CNV association studies. Ubiquitination is a post-translational modification that can alter protein function and target proteins for proteosome degradation. This system can regulate synaptic attributes, including neurotransmitter release, synaptic vesicle recycling in pre-synaptic terminals, dynamic changes in dendritic spines, and post-synaptic density. All four of the genes are ubiquitin-protein ligases.  UBE3A is the most studied of the four in relation to autism and PARK2 mutations have been linked to autosomal reccessive juvenile Parkinson's disease. <sup>1</sup>  </div></td></tr>
</table>
Deanna
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2367&oldid=prev
128.97.66.134 at 19:20, 16 November 2009
2009-11-16T19:20:27Z
<p></p>
<table class='diff diff-contentalign-left'>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:20, 16 November 2009</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10" >Line 10:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Alteration of the ubiquitin proteasome system(UPS) or mutations in the target proteins result in signaling abnormalities in the brain.  A dysregulated UPS can also perturb DNA replication and mitotic control mechanisms to lead to genomic instability.  In neurodegenerative diseases caused by mutant protein expression, the amount of mutant proteins can overwhelm the UPS and indirectly contribute to the disease process. <sup>2</sup>  </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[Links| Back to <del class="diffchange diffchange-inline">Main Page</del>]]</div></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;">[[Links| Back to <ins class="diffchange diffchange-inline">Links</ins>]]</div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br><br><br></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>====References====</div></td></tr>
</table>
128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2366&oldid=prev
128.97.66.134 at 19:20, 16 November 2009
2009-11-16T19:20:06Z
<p></p>
<table class='diff diff-contentalign-left'>
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<col class='diff-content' />
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<col class='diff-content' />
<tr style='vertical-align: top;' lang='en'>
<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:20, 16 November 2009</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l5" >Line 5:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Ubiquitin may be responsible for the turnover of synaptic components such as neuronal cell-adhesion molecules in a process that involves regulation of activity-dependent synaptic plasticity. Other ubiquitin related genes such as NHLRC1, UBR, CUL4B, BRwD3, and HUWE1 are involved in human neurological diseases. Mutations in the last three and UBE2A cause syndromes including intellectual disability.<sup>1</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Ubiquitin may be responsible for the turnover of synaptic components such as neuronal cell-adhesion molecules in a process that involves regulation of activity-dependent synaptic plasticity. Other ubiquitin related genes such as NHLRC1, UBR, CUL4B, BRwD3, and HUWE1 are involved in human neurological diseases. Mutations in the last three and UBE2A cause syndromes including intellectual disability.<sup>1</sup>  </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br></div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div><br><br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Ubiquitination Process'''</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===</ins>'''Ubiquitination Process'''<ins class="diffchange diffchange-inline">===</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>In this process, a small protein ubiquitin is covalently attached to lysine residues on the target protein via peptide bonds. Additional ubiquitin monomers are often added onto the first ubiquitin to form a chain of 4-7 ubiquitin monomers.  Ubiquitin with the attached ubiquitin is then guided to the protease complex 26S proteasome, located in the nucleus and cytoplasm of mammalian cells, where the protein is degraded. Ubiquitination targets oxidized, mutant, or misfolded proteins for general proteolytic destruction.  Ubiquitination also allows for tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>In this process, a small protein ubiquitin is covalently attached to lysine residues on the target protein via peptide bonds. Additional ubiquitin monomers are often added onto the first ubiquitin to form a chain of 4-7 ubiquitin monomers.  Ubiquitin with the attached ubiquitin is then guided to the protease complex 26S proteasome, located in the nucleus and cytoplasm of mammalian cells, where the protein is degraded. Ubiquitination targets oxidized, mutant, or misfolded proteins for general proteolytic destruction.  Ubiquitination also allows for tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. <sup>2</sup>  </div></td></tr>
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</table>
128.97.66.134
http://lcni-3.uoregon.edu/phenowiki/index.php?title=Ubiquitin&diff=2365&oldid=prev
128.97.66.134 at 19:19, 16 November 2009
2009-11-16T19:19:49Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 19:19, 16 November 2009</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Ubiquitin may be responsible for the turnover of synaptic components such as neuronal cell-adhesion molecules in a process that involves regulation of activity-dependent synaptic plasticity. Other ubiquitin related genes such as NHLRC1, UBR, CUL4B, BRwD3, and HUWE1 are involved in human neurological diseases. Mutations in the last three and UBE2A cause syndromes including intellectual disability.<sup>1</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Ubiquitin may be responsible for the turnover of synaptic components such as neuronal cell-adhesion molecules in a process that involves regulation of activity-dependent synaptic plasticity. Other ubiquitin related genes such as NHLRC1, UBR, CUL4B, BRwD3, and HUWE1 are involved in human neurological diseases. Mutations in the last three and UBE2A cause syndromes including intellectual disability.<sup>1</sup>  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><br><br></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>'''Ubiquitination Process'''</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>'''Ubiquitination Process'''</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>In this process, a small protein ubiquitin is covalently attached to lysine residues on the target protein via peptide bonds. Additional ubiquitin monomers are often added onto the first ubiquitin to form a chain of 4-7 ubiquitin monomers.  Ubiquitin with the attached ubiquitin is then guided to the protease complex 26S proteasome, located in the nucleus and cytoplasm of mammalian cells, where the protein is degraded. Ubiquitination targets oxidized, mutant, or misfolded proteins for general proteolytic destruction.  Ubiquitination also allows for tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. <sup>2</sup>  </div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>In this process, a small protein ubiquitin is covalently attached to lysine residues on the target protein via peptide bonds. Additional ubiquitin monomers are often added onto the first ubiquitin to form a chain of 4-7 ubiquitin monomers.  Ubiquitin with the attached ubiquitin is then guided to the protease complex 26S proteasome, located in the nucleus and cytoplasm of mammalian cells, where the protein is degraded. Ubiquitination targets oxidized, mutant, or misfolded proteins for general proteolytic destruction.  Ubiquitination also allows for tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. <sup>2</sup>  </div></td></tr>
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128.97.66.134