Difference between revisions of "Serum Protein Profiling"
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Proteomic tools can be used to find quantitative and qualitative protein patterns in many different tissues, which can be useful for finding specific diagnostic criteria or biomarkers. They can be used to identify differentially expressed genes, or analyzed for whole protein patterns.<sup>1</sup> | Proteomic tools can be used to find quantitative and qualitative protein patterns in many different tissues, which can be useful for finding specific diagnostic criteria or biomarkers. They can be used to identify differentially expressed genes, or analyzed for whole protein patterns.<sup>1</sup> | ||
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Established biomarkers could lead to earlier and more reliable diagnosis of ASD. Altered blood levels of neurotrophic factors have been reported, as well as associations of cytokines and chemokines with ASD. <sup>1</sup> | Established biomarkers could lead to earlier and more reliable diagnosis of ASD. Altered blood levels of neurotrophic factors have been reported, as well as associations of cytokines and chemokines with ASD. <sup>1</sup> | ||
Revision as of 12:18, 21 July 2010
Contents
Serum Protein Profiling
Basic Characteristics
- Description
Protein Profiling has been used in the past to find biomarkers for both non-psychiatric and psychiatric disorders. Some argue that studying proteins is more informative for finding the underlying pathophysiology of a disorder.
Proteomic tools can be used to find quantitative and qualitative protein patterns in many different tissues, which can be useful for finding specific diagnostic criteria or biomarkers. They can be used to identify differentially expressed genes, or analyzed for whole protein patterns.1
- Serum Protein Profiling and Autism Spectrum Disorder
Established biomarkers could lead to earlier and more reliable diagnosis of ASD. Altered blood levels of neurotrophic factors have been reported, as well as associations of cytokines and chemokines with ASD. 1
- Methods
There are different methods of analyzing proteins, depending on the purpose. Peptide Analysis MALDI-ToF-MS
Concerns
References
1. Taurines R. et. al. Serum protein profiling and proteomics in autistic spectrum disorder using magnetic bead-assisted mass spectrometry.Eur Arch Psychiatry Clin Neurosci. 2010 Apr;260(3):249-55 PMID 19784855
