Patient Medication Status

LA2K Patients: Medication Status

Data are based off of the Medication Status form as coded in the HTAC databse (downloaded 5/31/12); the following was conducted by EC, KK, AB in consultation with RMB.

N = 257 patients with a completed Medication Status form (83 SZ, 89 BP, 85 ADHD), but many of these are not valid/completers. The following data are based on the N = 153 patients whose Status = Complete and with complete Medication Status Forms (58 SZ, 49 BP, 46 ADHD).

I. We categorized the specific drugs entered into 11 main categories:
1. Antipsychotic
2. Psychostimulant
3. Antidepressant
4. Anticonvulsant-Mood Stabilizer
5. Sedative-Hypnotic
6. Analgesic
7. Hormone
8. Anxiolytic
9. Antiparkinsonian
10. Anticholinergic
11. Other (includes: Cannabis, SNRI, Antihypertensive, Antihistamine, Anoretic, Xyrem, Modafanil)

II. We determined a fixed washout time window for each specific drug, then took the max within each category, and applied that fixed washout time window for each drug within that category to determine Current Use.
A. Following consultation with Cesi, we used Pavuluri, M. N. & Janicak, P. G. Handbook of Psychopharmocology: A Life-Span Approach (2nd Edition). Philadelphia: Lippincott Williams and Wilkins (2009), to determine 10x the Half-Life of each specific drug.
B. The maximum time window was selected from each category.
C. This conservative washout time window was then applied for each specific drug within each category.
D. We then re-coded Current Use, as follows:
1. Current Use = 1 (no stop date entered, and use = 1)
2. Current Use = 1 (stop date entered that falls within the washout time window)
3. Current Use = 0 (stop date entered that falls outside the washout time window)

III.

IV.

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