Difference between revisions of "PTEN"
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| − | PTEN is a lipid phosphatase that negatively regulates the PI3K signaling pathway. | + | PTEN is a lipid phosphatase that negatively regulates the PI3K signaling pathway.<sup>1</sup> It primarily acts by counteracting the kinase ativity of PI3K and thereby inhibiting the activation of AKT. PTEN may be one of the genetic risk factors for ASD. Mice who have lost PTEN in vivo have a loss of neuronal polarity and neuronal hypertrophy. The TSC1/2 downstream pathway of PI3K/AKT is a candidate for facilitating these cellular changes. In one study which used rapamycin , a mTORC1 inhibitor, to study the TSC/MTORC1 pathway in Pten mutant mice, it was found that rapamycin blocks mTORC1 signaling in the CNS. Furthermore, Rapamycin can prevent or reverse macrocephaly in the Pten mutant mice.<sup>2</sup> |
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1. Stiles BL. '''Phosphatase and tensin homologue deleted on chromosome 10: Extending its | 1. Stiles BL. '''Phosphatase and tensin homologue deleted on chromosome 10: Extending its | ||
PTENtacles.''' Int J Biochem Cell Biol. 2009 Apr;41(4):757-61. PMID 18950730 | PTENtacles.''' Int J Biochem Cell Biol. 2009 Apr;41(4):757-61. PMID 18950730 | ||
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| + | 2. Zhou J et. al. '''Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.'''J Neurosci. 2009 Feb 11;29(6):1773-83. PMID 19211884 | ||
Revision as of 16:28, 23 November 2009
PTEN
PTEN is a lipid phosphatase that negatively regulates the PI3K signaling pathway.1 It primarily acts by counteracting the kinase ativity of PI3K and thereby inhibiting the activation of AKT. PTEN may be one of the genetic risk factors for ASD. Mice who have lost PTEN in vivo have a loss of neuronal polarity and neuronal hypertrophy. The TSC1/2 downstream pathway of PI3K/AKT is a candidate for facilitating these cellular changes. In one study which used rapamycin , a mTORC1 inhibitor, to study the TSC/MTORC1 pathway in Pten mutant mice, it was found that rapamycin blocks mTORC1 signaling in the CNS. Furthermore, Rapamycin can prevent or reverse macrocephaly in the Pten mutant mice.2
References
1. Stiles BL. Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr;41(4):757-61. PMID 18950730
2. Zhou J et. al. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.J Neurosci. 2009 Feb 11;29(6):1773-83. PMID 19211884
