PMID 14643087

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PMID 14643087

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  • Title

Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?

  • Authors

Johnson JK, Tuulio-Henriksson A, Pirkola T, Huttunen MO, Lönnqvist J, Kaprio J, Cannon TD

  • Year


  • Abstract

BACKGROUND: Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenic patients, but their relationship to each other and their potential common genetic source remain unclear. METHODS: Fifty unaffected co-twins of schizophrenic patients and 123 control twins were assessed with a neuropsychological battery and structured clinical interviews. RESULTS: Working memory was influenced by genetic risk for schizophrenia but not schizotypal symptoms. Nearly all other domains were influenced by schizotypy symptoms but only in the co-twins of schizophrenic patients. Schizotypy symptoms in the absence of a family history did not seem to be related to impaired neurocognitive functioning. CONCLUSIONS: Schizotypy symptoms in those with genetic risk for schizophrenia are associated with increased risk for cognitive deficits. Some neurocognitive deficits might covary with subpsychotic symptoms due to a shared genetic factor. Community-ascertained schizotypal individuals might not be appropriate for modeling underlying genetic risk for schizophrenia.

  • Keywords

Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Schizotypal Personality Disorder, Social Adjustment, Twins, Dizygotic, Twins, Monozygotic

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