Difference between revisions of "PLAUR"
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==PLAUR== | ==PLAUR== | ||
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| + | [[Image:Met pathway.gif|frame|MET pathway PMID 19339766]] | ||
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PLAUR has been implicated as an autism susceptibility gene<sup>1</sup> It is a part of the [[MET]] pathway and encodes the receptor for urokinase plasminogen activator. | PLAUR has been implicated as an autism susceptibility gene<sup>1</sup> It is a part of the [[MET]] pathway and encodes the receptor for urokinase plasminogen activator. | ||
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| − | More information about the gene and the proteins that bind its products can be found at the | + | More information about the gene and the proteins that bind its products can be found at the [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=retrieve&dopt=full_report&list_uids=5329 NCBI Entrez Gene Website] |
Latest revision as of 15:45, 14 July 2010
PLAUR
PLAUR has been implicated as an autism susceptibility gene1 It is a part of the MET pathway and encodes the receptor for urokinase plasminogen activator.
A study conducted by Eagleson (2010) with PLAUR knockout mice showed that there were reductions in GABAergic interneurons in the frontal and parietal regions of the cerebral cortex as well as the hippocampus and other areas. PLAUR KO mice exhibited increased sensitivity to pharmacologically-induced seizures, heightened anxiety, and aytpical social behavior. Additionally, specific GABAA receptor subunits were changed were changed in various areas of the frontal cortex, parietal cortex, and dentate gyrus. This demonstrates that disturbances with genes involved in the MET pathway may be able to account for GABAergic system disturbances seen in some people with ASD.2
More information about the gene and the proteins that bind its products can be found at the NCBI Entrez Gene Website
References
1.Campbell DB et. al. Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder. Autism Res. 2008 Jun;1(3):159-68. PMID 19360663
2. Eagleson KL et. al. Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABA(A) receptor subunit changes.Neuroscience. 2010 Apr 7 PMID 20381588
