Difference between revisions of "Methylation"
From Pheno Wiki
(Created page with 'One other hypothesis that may account for the widespread genetic defects found in ASD patients is that there may be abnormal methylation of brain-expressed genes on the X chromos…') |
|||
Line 1: | Line 1: | ||
+ | ==Methylation and ASD== | ||
One other hypothesis that may account for the widespread genetic defects found in ASD patients is that there may be abnormal methylation of brain-expressed genes on the X chromosome which in turn causes abnormal expression levels of genes important during development. These alternations cause one or more genes on the single X chromosome in males to be either partially silenced or over-expressed. This similarly happens in females, but the random X-chromosome inactivation might lesson autism predisposition and prevalence in females. This proposal is consistent with the findings that males make up a significantly larger amounts of ASD cases than females.<sup>2</sup> | One other hypothesis that may account for the widespread genetic defects found in ASD patients is that there may be abnormal methylation of brain-expressed genes on the X chromosome which in turn causes abnormal expression levels of genes important during development. These alternations cause one or more genes on the single X chromosome in males to be either partially silenced or over-expressed. This similarly happens in females, but the random X-chromosome inactivation might lesson autism predisposition and prevalence in females. This proposal is consistent with the findings that males make up a significantly larger amounts of ASD cases than females.<sup>2</sup> | ||
+ | <br><br><br><br> | ||
+ | <div style="float:left; padding:10px; background:yellow; border:2px solid black;font-size:large;"><b>[[Genetics]]</b></div> | ||
+ | |||
+ | <div style="float:right; padding:10px; background:yellow; border:2px solid black;font-size:large;"><b>[[Autism Spectrum Disorders| Main Page]]</b></div> | ||
+ | |||
+ | <br><br><br><br> | ||
+ | ====References==== |
Revision as of 13:40, 1 April 2010
Methylation and ASD
One other hypothesis that may account for the widespread genetic defects found in ASD patients is that there may be abnormal methylation of brain-expressed genes on the X chromosome which in turn causes abnormal expression levels of genes important during development. These alternations cause one or more genes on the single X chromosome in males to be either partially silenced or over-expressed. This similarly happens in females, but the random X-chromosome inactivation might lesson autism predisposition and prevalence in females. This proposal is consistent with the findings that males make up a significantly larger amounts of ASD cases than females.2