Difference between revisions of "Introduction"
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* Abstract | * Abstract | ||
− | + | The human genome project has stimulated development of impressive repositories of | |
biological knowledge at the genomic level and new knowledge bases are rapidly being | biological knowledge at the genomic level and new knowledge bases are rapidly being | ||
− | developed in a | + | developed in a ''bottom-up'' fashion. In contrast, higher-level phenomics knowledge bases are |
underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, | underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, | ||
symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to | symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to | ||
Line 31: | Line 31: | ||
tion and sharing of empirical information about phenotypes important to neuropsychiatric | tion and sharing of empirical information about phenotypes important to neuropsychiatric | ||
research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to | research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to | ||
− | + | ''cognitive control'', a neurocognitive construct considered important to multiple neuropsy- | |
chiatric syndromes. Currently this knowledge base tabulates empirical findings about | chiatric syndromes. Currently this knowledge base tabulates empirical findings about | ||
heritabilities and measurement properties of specific cognitive task and rating scale indicators | heritabilities and measurement properties of specific cognitive task and rating scale indicators | ||
(n = 449 observations). It is hoped that this new open resource can serve as a starting point that | (n = 449 observations). It is hoped that this new open resource can serve as a starting point that | ||
enables broadly collaborative knowledge-building, and help investigators select and prioritize | enables broadly collaborative knowledge-building, and help investigators select and prioritize | ||
− | endophenotypes for translational research. | + | endophenotypes for translational research. |
* Keywords | * Keywords | ||
Line 53: | Line 53: | ||
::Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see [http://cognitiveatlas.org cognitive atlas] project) | ::Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see [http://cognitiveatlas.org cognitive atlas] project) | ||
:The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric [http://www.google.com/search?hl=en&q=gwas gwas] studies | :The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric [http://www.google.com/search?hl=en&q=gwas gwas] studies | ||
− | [[Image:sabb1.jpg | frame |right | A figure that details the phenomics strategy that looks a multi-variate and multi-level phenotypes ]] | + | [[Image:sabb1.jpg | frame |right | 200px | A figure that details the phenomics strategy that looks a multi-variate and multi-level phenotypes ]] |
*Method | *Method |
Revision as of 11:36, 8 January 2010
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MANUSCRIPT ID
- Title
A collaborative knowledge base for cognitive phenomics
- Authors
FW Sabb, CE Bearden, DC Glahn, DS Parker, N Freimer and RM Bilder
- Year
2008
- Abstract
The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a bottom-up fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representa- tion and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to cognitive control, a neurocognitive construct considered important to multiple neuropsy- chiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n = 449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.
- Keywords
phenotype; cognition; heritability; genetics; cognitive control; informatics
- Input Author
fws
MANUSCRIPT DETAILS
- Introduction/Aims
- Refining cognitive and behavioral phenotypes is crucial for neuropsychiatry. Searching for genes and underlying biology of syndromes will be difficult unless the right phenotypes are being studied.
- Current endophenotypes are poorly understood
- Using informatics approaches to improve knowledge structure will help
- Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see cognitive atlas project)
- The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric gwas studies
- Method
A review paper/meta-analysis. see flow diagram for details.
- Results
- Discussion
MANUSCRIPT EXTRAS
- other Links out:
- Google 1580808
- Wikipedia 1580808
- PubBrain
- PMID 1580808
- PubAtlas - A tool developed to blast PubMed and create a heatmap of pairwise searches