Difference between revisions of "Introduction"

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::Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see [http://cognitiveatlas.org cognitive atlas] project)
 
::Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see [http://cognitiveatlas.org cognitive atlas] project)
 
:The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric [http://www.google.com/search?hl=en&q=gwas gwas] studies
 
:The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric [http://www.google.com/search?hl=en&q=gwas gwas] studies
[[Image:sabb1.jpg | frame |right | 200px | A figure that details the phenomics strategy that looks a multi-variate and multi-level phenotypes ]]
+
[[Image:sabb1.jpg | thumb |right | A figure that details the phenomics strategy that looks a multi-variate and multi-level phenotypes ]]
  
 
*Method
 
*Method

Revision as of 11:38, 8 January 2010

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PMID 18180765

MANUSCRIPT ID

  • Title

A collaborative knowledge base for cognitive phenomics

  • Authors

FW Sabb, CE Bearden, DC Glahn, DS Parker, N Freimer and RM Bilder

  • Year

2008

  • Abstract

The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a bottom-up fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representa- tion and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to cognitive control, a neurocognitive construct considered important to multiple neuropsy- chiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and measurement properties of specific cognitive task and rating scale indicators (n = 449 observations). It is hoped that this new open resource can serve as a starting point that enables broadly collaborative knowledge-building, and help investigators select and prioritize endophenotypes for translational research.

  • Keywords

phenotype; cognition; heritability; genetics; cognitive control; informatics

  • Input Author

fws

MANUSCRIPT DETAILS

  • Introduction/Aims
Refining cognitive and behavioral phenotypes is crucial for neuropsychiatry. Searching for genes and underlying biology of syndromes will be difficult unless the right phenotypes are being studied.
Current endophenotypes are poorly understood
Using informatics approaches to improve knowledge structure will help
Informatics tools get better as you get closer to the gene (BLAST and gene ontology), but are poor at the level of syndromes/symptoms/behavior (but see cognitive atlas project)
The aim of this paper was to develop a knowledgebase that focuses on these top levels to help examine and select relevant behavioral phenotypes for use in neuropsychiatric gwas studies
A figure that details the phenomics strategy that looks a multi-variate and multi-level phenotypes
  • Method

A review paper/meta-analysis. see flow diagram for details.

File:Sabb2.jpg
Flow of methods and procedure for the review and analysis
  • Results
File:Sabb3.jpg
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File:Sabb5.jpg
INSERT IMAGE from PAPER here
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  • Discussion


MANUSCRIPT EXTRAS