DIAPH3
From Pheno Wiki
Revision as of 12:23, 24 March 2010 by 128.97.66.134 (Talk)
DIAPH3
DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.1
References
1. Vorstman JA et. al. A double hit implicates DIAPH3 as an autism risk gene.Mol Psychiatry. 2010 Mar 23. PMID 20308993
