Difference between revisions of "DIAPH3"
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==DIAPH3== | ==DIAPH3== | ||
| − | DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.<sup>1</sup> | + | DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of [[Neuroligins/Neurexins/Shank3 | SHANK3]].<sup>1</sup> |
===Other Resources=== | ===Other Resources=== | ||
| − | + | *More information about the gene http://www.ncbi.nlm.nih.gov/gene | |
| − | + | *Site which gives genomic, transcriptomic, genetic, proteomic, functional and disease related information about human genes. http://www.genecards.org/ | |
Latest revision as of 14:28, 24 March 2010
DIAPH3
DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.1
Other Resources
- More information about the gene http://www.ncbi.nlm.nih.gov/gene
- Site which gives genomic, transcriptomic, genetic, proteomic, functional and disease related information about human genes. http://www.genecards.org/
References
1. Vorstman JA et. al. A double hit implicates DIAPH3 as an autism risk gene.Mol Psychiatry. 2010 Mar 23. PMID 20308993
