Difference between revisions of "DIAPH3"
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DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.<sup>1</sup> | DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.<sup>1</sup> | ||
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| + | ===Other Resources=== | ||
| + | **More information about the gene [http://www.ncbi.nlm.nih.gov/gene] | ||
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| + | **Site which gives genomic, transcriptomic, genetic, proteomic, functional and disease related information about human genes.[http://www.genecards.org/] | ||
Revision as of 14:15, 24 March 2010
DIAPH3
DIAPH3 is a gene that has recently been suggested as a novel susceptibility gene for autism which may have a function in the developing murine cerebral cortex. Murine fibroblasts that have been transfected with a amino acid substitution Pro614Thr at DIAPH3 showed a significant reduction in the number of induced filopodia. DIAPH3 is involved in cell migration, axon guidance and neuritogeneis and has been suggested to work downstream of SHANK3.1
Other Resources
- More information about the gene [1]
- Site which gives genomic, transcriptomic, genetic, proteomic, functional and disease related information about human genes.[2]
References
1. Vorstman JA et. al. A double hit implicates DIAPH3 as an autism risk gene.Mol Psychiatry. 2010 Mar 23. PMID 20308993
