Abnormal Cellular/Synaptic Growth Hypothesis
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Revision as of 11:35, 26 October 2009 by Deanna (Talk | contribs) (Created page with '==Abnormal Cellular/Synaptic Growth Hypothesis== This hypothesis came from studies of Tuberouse Schlerosis and Cowden/Lhermitte-Cuclos Syndromes where it was found that the two …')
Abnormal Cellular/Synaptic Growth Hypothesis
This hypothesis came from studies of Tuberouse Schlerosis and Cowden/Lhermitte-Cuclos Syndromes where it was found that the two syndromes associate susceptibility to Autism Spectrum Disorders with macrocephaly. Macrocephaly is relatively common among ASD patients with an estimated prevalence rate of 20%.
Tuberouse Schlerosis and Cowden/Lhermitte-Cuclos Syndrome are caused by NF1, TSC1/TSC2, and PTEN. These proteins act as negative effectors of mTORC1, which is a regular
