Response inhibition in ASD

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Response inhibition

  • Definition

See Response Inhibition

  • Response Inhibition in ASD

Neuroimaging studies indicate that response inhibition deficits reflect abnormalities in frontal circuits. ASD is not, however, a disorder of inhibitory dysfunction. Many other developmental disorders including ADHD and OCD also show a disruption in normal response inhibition processes.

Results from studies on response inhibition in autism are conflicting. The paradigm chosen to test response inhibition, age, and level of function can control whether a deficit is seen in those with ASD. For example, the Stroop and the Flanker tasks involve attention switching mechanisms, which may be intact in ASD people. The Interference suppression seen in these tasks may allow those with high functioning autism then to compensate for a response inhibition deficit.

Studies suggest that brain maturation processes such as synaptic pruning and myelination in frontal and temporal regions is intact in those with ASD.1

References

1. O'Hearn K et. al. Neurodevelopment and executive function in autism.Dev Psychopathol. 2008 Fall;20(4):1103-32. PMID 18838033