PMID 16855083
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Contents
Title
Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory.
Authors
Cátia M. Teixeira, Stephen R. Pomedli, Hamid R. Maei, Nohjin Kee, and Paul W. Frankland
Year
2006
Abstract
Although the hippocampus plays a crucial role in the formation of spatial memories, as these memories mature they may become additionally (or even exclusively) dependent on extrahippocampal structures. However, the identity of these extrahippocampal structures that support remote spatial memory is currently not known. Using a Morris water-maze task, we show that the anterior cingulate cortex (ACC) plays a key role in the expression of remote spatial memories in mice. To first evaluate whether the ACC is activated after the recall of spatial memory, we examined the expression of the immediate early gene, c-fos, in the ACC. Fos expression was elevated after expression of a remote (1 month old), but not recent (1 d old), water-maze memory, suggesting that ACC plays an increasingly important role as a function of time. Consistent with the gene expression data, targeted pharmacological inactivation of the ACC with the sodium channel blocker lidocaine blocked expression of remote, but spared recent, spatial memory. In contrast, inactivation of the dorsal hippocampus disrupted expression of spatial memory, regardless of its age. We further showed that inactivation of the ACC blocked expression of remote spatial memory in two different mouse strains, after training with either a hidden or visible platform in a constant location, and using the AMPA receptor antagonist CNQX. Together, our data provide evidence that circuits supporting spatial memory are reorganized in a time-dependent manner, and establish that activity in neurons intrinsic to the ACC is critical for processing remote spatial memories.
Keywords
hippocampus; spatial learning; Fos; lidocaine; CNQX; memory consolidation
Reference
doi:10.1523/JNEUROSCI.1068-06.2006
Input Author
A Howe
Notes
long term memory spatial memory depends on anterior cingulate cortex (ACC)
significant increase in cfos expression in the ACC for a spatial memory task
CA1 and CA3 show significant FOS increase relative to home cage, but no difference exists across memory tasks
compared to control injections of PBS :
lidocane into ACC significantly decreases performance on long term recall, with no significant effect on short term memory
lidocane into dorsal hippocampus (dHPC) decreases both long term recall and short term recall performance
usage of CNQX instead of lidocaine does not change the result (the behavior does not depend on blockade of inhibitory neurons and/or passing fibers)
Assertions
ACC == anterior cingulate cortex
ACC -- long term memory
ACC -- spatial memory consolidation
ACC !-- short term memory
ACC !-- working memory
ACC !-- spatial working memory
dHPC -- long term memory
dHPC -- spatial processing
dHPC -- short term memory
dHPC == dorsal hippocampus
CA1 -- spatial navigation
CA3 -- spatial navigation
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